How to use

Frequently Asked Questions

Company FAQs

SQ Innovation is a pharmaceutical company located in Burlington, MA. For more information, visit www.sqinnovation.com

For information about current employment opportunities at SQ Innovation, please visit our LinkedIn page to view open positions

For media or press inquiries, email pr-media@sqinnovation.com 

Product FAQs

Lasix ONYU is a prescription drug-device combination that treats edema caused by fluid build-up in a person with heart failure.

Lasix ONYU is a combination device. It uses a small infusor that adheres to the abdomen to deliver an IV-strength furosemide formulation, subcutaneously (under the skin) via a small gauge needle.

Lasix ONYU is intended for use in adults patients with chronic heart failure who have edema, as directed by their healthcare provider.

The U.S. Food and Drug Administration (FDA) granted approval for Lasix ONYU for the treatment of edema in adult patients with chronic heart failure on October 7, 2025.

For dossier requests, email medinfo@sqinnovation.com

For the SDS, please visit www.lasix-onyu.com and navigate to the Helpful Resources section, or email medinfo@sqinnovation.com to request a copy.

Product Access & Availability

Lasix ONYU will be commercially available later this year. 

Lasix ONYU is a prescription pharmaceutical and will be available through leading pharmaceutical distributors. 

Coverage for Lasix ONYU may vary by insurance plan. Patients should check with their insurer for details.

The product will have list price (WAC) of approximately $500 per treatment. Patient out-of-pocket cost may vary based on insurance coverage and other factors.

Our strategy is to have the product widely available at a affordable co-pay, therefore, there are no patient support programs available. For questions regarding reimbursement, patients should contact their insurance provider.

For additional information or inquiries, please contact interest@sqinnovation.com

SQ Innovation is hosting virtual information sessions, which healthcare providers can request a registration link by completing this form. For questions or to contact the Field Team, please email interest@sqinnovation.com.

What is Lasix® ONYU (furosemide injection) for subcutaneous use?

Lasix ONYU is a prescription drug-device combination that treats edema caused by fluid build-up in a person with heart failure. Lasix ONYU comes with a special device that delivers the medicine under the skin. Follow the instructions provided by your healthcare provider when using Lasix ONYU.

IMPORTANT SAFETY INFORMATION

Before using Lasix ONYU, read the Instructions for Use and tell your healthcare provider about all your medical conditions, including if you are allergic to furosemide or any of the ingredients in Lasix ONYU, have trouble urinating, or if you are allergic to medical adhesives.

Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines.

Warning: Only use the Lasix ONYU Prefilled Cartridge with the Lasix ONYU Infusor. Do not use insulin cartridges or other medicine cartridges in the Lasix ONYU Infusor. Doing so could cause severe injury.

What are the possible side effects of Lasix ONYU?

Dehydration: Lasix ONYU is a diuretic that can make you lose a lot of fluid and with it electrolytes. You may get a dry mouth, have increased thirst, get muscle pains or cramps, have reduced urine output or your urine may be more yellow than normal, you may get a headache, get dry skin, or have nausea or vomiting. Your healthcare provider may check your electrolytes while receiving Lasix ONYU.

Low Blood Pressure: Lasix ONYU may lower your blood pressure temporarily. You may feel lightheaded or dizzy. This usually happens when you stand. Getting up slowly may help.

High Blood Sugar: Lasix ONYU may increase blood sugar (glucose) levels if you have diabetes mellitus.

Loss of Hearing: Lasix ONYU can cause ringing in your ears. If so tell your healthcare provider.

Risk of Sunburn: Your skin may be more sensitive to sunlight while taking Lasix ONYU.

Infusion Site Reactions: Lasix ONYU can cause infusion site pain, bruising, and temporary swelling or redness at the site of the Infusor.

Incomplete Dosing: Make sure the Infusor does not get wet during use. Also limit your physical activities.  Some movements or when it gets wet may stop the infusion and you may not get all the medication.

These are not all the possible side effects of Lasix ONYU. For more information, ask your healthcare provider or pharmacist.

Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Please see Lasix® ONYU full Prescribing Information and Instructions for Use.

INDICATION & LIMITATION OF USE

Lasix® ONYU is a prescription drug-device combination that treats edema in adult patients with chronic heart failure.  It enables treatment outside the healthcare setting as instructed by a healthcare provider.

INDICATION AND USAGE

Lasix ONYU is indicated for the treatment of edema in adult patients with chronic heart failure.

Contraindications

  • Lasix ONYU is contraindicated in patients with anuria.
  • Lasix ONYU is contraindicated in patients with a history of hypersensitivity to furosemide or medical adhesives.
  • Lasix ONYU is contraindicated in patients with hepatic cirrhosis.

 

Warnings and Precautions

  • Fluid, Electrolyte, and Metabolic Abnormalities: Monitor serum electrolytes, CO2, BUN, creatinine, glucose, and uric acid.
  • Worsening Renal Function: Monitor for dehydration and azotemia.
  • Ototoxicity: Avoid higher than recommended doses.
  • Acute Urinary Retention: Monitor patients with symptoms of urinary retention.
  • Incomplete Dosing: Fluid contact and certain patient movements during treatment may cause the On-body Infusor to prematurely terminate infusion. Ensure patients can detect and respond to alarms.

Adverse Reactions

The most common adverse reactions during treatment with the Lasix ONYU Infusor were administration site and skin reactions: erythema, bruising, edema, and infusion site pain.

Drug Interactions

  • Aminoglycoside antibiotics: Increased potential ototoxicity of the antibiotics. Avoid combination.
  • Ethacrynic acid: Risk of ototoxicity. Avoid combination.
  • Salicylates: Risk of salicylate toxicity.
  • Cisplatin and nephrotoxic drugs: Risk of ototoxicity and nephrotoxicity.
  • Lithium: Risk of lithium toxicity.
  • Renin-angiotensin inhibitors: Increased risk of hypotension and renal failure.
  • Adrenergic blocking drugs: Risk of potentiation.
  • Drugs undergoing renal tubular secretion: Risk of toxicity potentiation.

Please see Lasix® ONYU full Prescribing Information and Instructions for Use.