How to use

SQ Innovation is a privately held Swiss biopharmaceutical company located in Zug, Switzerland, and Burlington, Massachusetts, United States.

SQ Innovation was established in 2019 to develop and commercialize innovative cost-effective therapies based on subcutaneous delivery of pharmaceutical products.

The parent company is located in Zug, Switzerland, but we operate out of in Burlington, MA. 

Product innovation is our space. This is why we named the company SQ Innovation. We invented the now patented high concentration drug formulation. For our Infusor device, we partnered with Gerresheimer — a leading manufacturer of drug delivery systems and pharmaceutical drug containers headquartered in Germany. 

At SQ Innovation, we are committed to delivering high-quality, innovative medical devices that are both affordable and designed to meet real-world clinical needs.

Lasix ONYU, our first FDA-approved product, combines a high-concentration formulation of furosemide with a wearable Infusor for subcutaneous delivery in adult patients with chronic heart failure experiencing fluid overload. Approved in the U.S. in October 2025, regulatory reviews are also in progress in Europe and the UK.

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Contact Information

SQ Innovation, Inc

20 Mall Road, Suite 220

Burlington, MA 01803

USA

Website: www.sqinnovation.com


Telephone: +1 (781) 202-5000

Email: info@sqinnovation.com

Our Values

Trust

We provide dependable products that meet customer expectations and improve patient care.

Talent

We value our people and their contributions towards operational excellence.

Innovation

We aim to design and develop transformative products for the benefit of patients and society.

Collaboration

We partner with our customers and suppliers so that we all win in the end,

What is Lasix® ONYU (furosemide injection) for subcutaneous use?

Lasix ONYU is a prescription drug-device combination that treats edema caused by fluid build-up in a person with heart failure. Lasix ONYU comes with a special device that delivers the medicine under the skin. Follow the instructions provided by your healthcare provider when using Lasix ONYU.

IMPORTANT SAFETY INFORMATION

Before using Lasix ONYU, read the Instructions for Use and tell your healthcare provider about all your medical conditions, including if you are allergic to furosemide or any of the ingredients in Lasix ONYU, have trouble urinating, or if you are allergic to medical adhesives.

Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines.

Warning: Only use the Lasix ONYU Prefilled Cartridge with the Lasix ONYU Infusor. Do not use insulin cartridges or other medicine cartridges in the Lasix ONYU Infusor. Doing so could cause severe injury.

What are the possible side effects of Lasix ONYU?

Dehydration: Lasix ONYU is a diuretic that can make you lose a lot of fluid and with it electrolytes. You may get a dry mouth, have increased thirst, get muscle pains or cramps, have reduced urine output or your urine may be more yellow than normal, you may get a headache, get dry skin, or have nausea or vomiting. Your healthcare provider may check your electrolytes while receiving Lasix ONYU.

Low Blood Pressure: Lasix ONYU may lower your blood pressure temporarily. You may feel lightheaded or dizzy. This usually happens when you stand. Getting up slowly may help.

High Blood Sugar: Lasix ONYU may increase blood sugar (glucose) levels if you have diabetes mellitus.

Loss of Hearing: Lasix ONYU can cause ringing in your ears. If so tell your healthcare provider.

Risk of Sunburn: Your skin may be more sensitive to sunlight while taking Lasix ONYU.

Infusion Site Reactions: Lasix ONYU can cause infusion site pain, bruising, and temporary swelling or redness at the site of the Infusor.

Incomplete Dosing: Make sure the Infusor does not get wet during use. Also limit your physical activities.  Some movements or when it gets wet may stop the infusion and you may not get all the medication.

These are not all the possible side effects of Lasix ONYU. For more information, ask your healthcare provider or pharmacist.

Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Please see Lasix® ONYU full Prescribing Information and Instructions for Use.

INDICATION & LIMITATION OF USE

Lasix® ONYU is a prescription drug-device combination that treats edema in adult patients with chronic heart failure.  It enables treatment outside the healthcare setting as instructed by a healthcare provider.

INDICATION AND USAGE

Lasix ONYU is indicated for the treatment of edema in adult patients with chronic heart failure.

Contraindications

  • Lasix ONYU is contraindicated in patients with anuria.
  • Lasix ONYU is contraindicated in patients with a history of hypersensitivity to furosemide or medical adhesives.
  • Lasix ONYU is contraindicated in patients with hepatic cirrhosis.

 

Warnings and Precautions

  • Fluid, Electrolyte, and Metabolic Abnormalities: Monitor serum electrolytes, CO2, BUN, creatinine, glucose, and uric acid.
  • Worsening Renal Function: Monitor for dehydration and azotemia.
  • Ototoxicity: Avoid higher than recommended doses.
  • Acute Urinary Retention: Monitor patients with symptoms of urinary retention.
  • Incomplete Dosing: Fluid contact and certain patient movements during treatment may cause the On-body Infusor to prematurely terminate infusion. Ensure patients can detect and respond to alarms.

Adverse Reactions

The most common adverse reactions during treatment with the Lasix ONYU Infusor were administration site and skin reactions: erythema, bruising, edema, and infusion site pain.

Drug Interactions

  • Aminoglycoside antibiotics: Increased potential ototoxicity of the antibiotics. Avoid combination.
  • Ethacrynic acid: Risk of ototoxicity. Avoid combination.
  • Salicylates: Risk of salicylate toxicity.
  • Cisplatin and nephrotoxic drugs: Risk of ototoxicity and nephrotoxicity.
  • Lithium: Risk of lithium toxicity.
  • Renin-angiotensin inhibitors: Increased risk of hypotension and renal failure.
  • Adrenergic blocking drugs: Risk of potentiation.
  • Drugs undergoing renal tubular secretion: Risk of toxicity potentiation.

Please see Lasix® ONYU full Prescribing Information and Instructions for Use.